[Extra-pyramidal syndrome induced by donepezil].
作者信息
Carcenac D, Martin-Hunyadi C, Kiesmann M, Demuynck-Roegel C, Alt M, Kuntzmann F
机构信息
Hôpital de Jour d'Evaluation Gériatrique et Gérontologique Saint-François, CHUR de Strasbourg.
出版信息
Presse Med. 2000 May 20;29(18):992-3.
BACKGROUND
The cholinergic hypothesis of Alzheimer's disease is the basis of a new class of drugs: acetylcholinesterase inhibitors. These drugs have few side effects, mainly digestive disorders.
CASE REPORTS
Extra-pyramidal side effects with severe gait disorders were observed in 3 patients with Alzheimer's dementia treated with donepezil. This drug was associated with paroxetine or a neuroleptic. In 2 of the 3 cases, the extra-pyramidal effects disappeared when donepezil was discontinued.
DISCUSSION
Extra-pyramidal syndromes in elderly subjects with cognitive impairment are difficult to interpret. The possible causes include interactions between acetylcholinesterase inhibitors, neuroleptics and serotonine reuptake inhibitors and Lewy body dementia.
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