Khanna N, Bhalla S
Department of Pharmacology, University College of Medical Sciences, Shahdara, Delhi.
Indian J Med Sci. 1999 Nov;53(11):475-80.
It can be concluded from the present study that ketamine showed dose-dependent anticonvulsant effect on MES in mice. It is presumed that this anticonvulsant effect of ketamine could be due to blockade of excitatory amino acid NMDA receptors. It was potentiated by anticonvulsants like diazepam and DPH but was found to be insensitive to naloxone. These findings suggest the involvement of NMDA receptors and their antagonists in epilepsy. Ketamine thus can be given as add-on therapy in refractory cases, and may prove to be useful as an anticonvulsant in future.
从本研究可以得出结论，氯胺酮对小鼠最大电休克发作（MES）显示出剂量依赖性抗惊厥作用。据推测，氯胺酮的这种抗惊厥作用可能是由于阻断了兴奋性氨基酸NMDA受体。它被地西泮和苯妥英等抗惊厥药增强，但对纳洛酮不敏感。这些发现表明NMDA受体及其拮抗剂与癫痫有关。因此，氯胺酮可作为难治性病例的附加治疗药物，并且未来可能被证明是一种有用的抗惊厥药。
