Shukla J S, Chaudhary R K
Department of Transfusion Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Indian J Pathol Microbiol. 1999 Jul;42(3):299-302.
Red blood cell (RBC) transfusions are frequently used in the management of patients with chronic renal failure (CRF) undergoing hemodialysis for dialysis-related anaemia. Consequently, they are subject to all hazards associated with repeated transfusions, such as red cell alloimmunization. A retrospective study was performed to estimate the frequency of alloimmunization against red cell antigens in multitransfused CRF patients. A total of 81 patients (67 males & 14 females) with CRF were studied who received a mean of 8.5 units of RBC matched for ABO & Rh(D) antigens only. Using standard techniques (indirect antiglobulin test, enzyme, polyethylene glycol, and low ionic strength solution), we observed a RBC alloimmunization rate of 9.8% (8/81). Nine alloantibodies were detected in 8 patients, and most (88%) involved antigens in the Rhesus & Kell systems. No correlation was observed with the alloantibody formation & number of units transfused. The calculated risk of 1.3% observed in the present study, suggests that renal failure patients are not at a higher risk of red cell alloimmunization than the general population.
红细胞（RBC）输血常用于治疗因透析相关贫血而接受血液透析的慢性肾衰竭（CRF）患者。因此，它们会面临与反复输血相关的所有风险，如红细胞同种免疫。进行了一项回顾性研究，以评估多次输血的CRF患者中红细胞抗原同种免疫的频率。共研究了81例CRF患者（67例男性和14例女性），他们平均接受了仅针对ABO和Rh（D）抗原匹配的8.5单位红细胞。使用标准技术（间接抗球蛋白试验、酶、聚乙二醇和低离子强度溶液），我们观察到红细胞同种免疫率为9.8%（8/81）。在8例患者中检测到9种同种抗体，大多数（88%）涉及恒河猴和凯尔系统中的抗原。未观察到同种抗体形成与输血量之间的相关性。本研究中观察到的1.3%的计算风险表明，肾衰竭患者发生红细胞同种免疫的风险并不高于普通人群。
