慢性肝病中的玫瑰花结抑制试验。
Rosette inhibition test in chronic liver disease.
作者信息
Salerno F, Fargion S R, Cappellini M D, Fiorelli G, Dioguardi N
出版信息
J Clin Pathol. 1976 Sep;29(9):778-81. doi: 10.1136/jcp.29.9.778.
A role has recently been assigned to cell-mediated immunity in chronic liver diseases in addition to the well-known alterations of humoral immunity. We now report the results of the rosette inhibition test for the evaluation of T-lymphocyte "sensitization" in patients with different chronic liver disorders. A cell-mediated immune reaction was found in 81% of patients with chronic active hepatitis and in 71% with primary biliary cirrhosis, whereas patients with chronic persistent hepatitis showed no reaction. The correlation with the incidence of hepatitis B antigen showed that T-lymphocyte sensitization was more frequent in the group of HB-positive patients. Finally, improvement of the test was observed in four out of nine patients given immunosuppressive treatment.
除了众所周知的体液免疫改变外，细胞介导的免疫最近在慢性肝病中也被赋予了一定作用。我们现在报告玫瑰花结抑制试验的结果，以评估不同慢性肝病患者的T淋巴细胞“致敏”情况。在81%的慢性活动性肝炎患者和71%的原发性胆汁性肝硬化患者中发现了细胞介导的免疫反应，而慢性持续性肝炎患者未出现反应。与乙肝抗原发生率的相关性表明，T淋巴细胞致敏在HB阳性患者组中更为常见。最后，在接受免疫抑制治疗的9名患者中，有4名患者的试验结果有所改善。
Zotero 插件