Yoshida M, Noguchi E, Tsuru N
Department of Neurology, Division for the Visually Impaired, Tsukuba College of Technology, Kasuga 4-12-7, City of Tsukuba, 305, Ibaraki, Japan.
Epilepsy Res. 2000 Jul;40(2-3):141-5. doi: 10.1016/s0920-1211(00)00115-7.
We investigated whether some histamine H(3)-antagonists would attenuate amygdaloid kindled seizures in rats. Thioperamide, a standard H(3)-antagonist, did not significantly reduce either seizure ranks or afterdischarge duration (ADD). Betahistine which has both H(3)-antagonistic activity and H(1)-agonistic activity significantly reduced ADD, albeit mild at a toxic dose, though seizure ranks were not affected. In addition, L-histidine, the precursor of histamine, affected neither seizure ranks, nor ADD. It was shown that H(3)-antagonists have no significant inhibitory action against amygdaloid kindled seizures, probably because released histamine was unable to inhibit those seizures.
我们研究了某些组胺H(3)拮抗剂是否会减轻大鼠杏仁核点燃性癫痫发作。标准的H(3)拮抗剂硫代乙酰胺并未显著降低癫痫发作等级或后放电持续时间（ADD）。兼具H(3)拮抗活性和H(1)激动活性的倍他司汀虽在毒性剂量下对ADD有显著降低作用，但作用较弱，且对癫痫发作等级无影响。此外，组胺的前体L-组氨酸对癫痫发作等级和ADD均无影响。结果表明，H(3)拮抗剂对杏仁核点燃性癫痫发作无显著抑制作用，可能是因为释放的组胺无法抑制这些癫痫发作。
