Kakinoki H, Ishizawa K, Fukunaga M, Fujii Y, Kamei C
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Brain Res Bull. 1998 Jul 15;46(5):461-5. doi: 10.1016/s0361-9230(98)00048-3.
The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H3-agonist [(R)-alpha-methylhistamine] and H1-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H2-antagonist (cimetidine and ranitidine) caused no antagonistic effect. Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment.
