Haugaard N
Department of Pharmacology, University of Pennsylvania, Philadelphia 19104, USA.
Ann N Y Acad Sci. 2000;899:148-58. doi: 10.1111/j.1749-6632.2000.tb06183.x.
This essay is concerned with the role of the thiol or sulfhydrvl group in cellular function and metabolism and with the important investigations over many years that have led us to a better understanding of the importance of this molecular moiety that plays such a vital role in biology. The tools for measuring the SH group and for inhibiting or regenerating it will be discussed as will its essential role in the actions of many enzymes. The importance of the thiol group in glycolysis and in energy production by mitochondria will be emphasized. Of special interest at present is the fact that certain low molecular weight SH-containing substances can mimic some of the actions of insulin and may become of benefit in the treatment of diabetes mellitus. Finally, the toxic effects of oxygen on metabolism and function will be discussed with particular reference to the possibility that oxidation of thiol groups may play a role in the manifestations of oxygen toxicity.
本文关注硫醇或巯基在细胞功能和代谢中的作用，以及多年来的重要研究，这些研究使我们更好地理解了这个在生物学中起着至关重要作用的分子部分的重要性。将讨论测量巯基以及抑制或再生巯基的工具，以及它在许多酶的作用中的重要作用。将强调巯基在糖酵解和线粒体能量产生中的重要性。目前特别令人感兴趣的是，某些含低分子量巯基的物质可以模拟胰岛素的一些作用，可能对糖尿病的治疗有益。最后，将讨论氧对代谢和功能的毒性作用，特别提及巯基氧化可能在氧中毒表现中起作用的可能性。
