Sanae F, Komatsu Y, Amagaya S, Chisaki K, Hayashi H
Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
Biol Pharm Bull. 2000 Jun;23(6):762-5. doi: 10.1248/bpb.23.762.
We examined the effects of 9 kinds of Kampo medicines, which are clinically used for the treatment of hypertension, on anesthetized rats with increases in arterial blood pressure, heart rate and peripheral blood flow induced by theophylline (5 mg/kg, i.v.) that were partially or completely mediated by endogenous catecholamines. Each Kampo medicine (1 g/kg) was intraduodenaly administered. Shinbu-to caused a severe disturbance of the arterial blood pressure. Saiko-ka-ryukotsu-borei-to, Oren-gedoku-to, San'o-shashin-to and Dai-jyoki-to had hypotensive effects, while Hachimi-jio-gan, Gosha-jinki-gan, Dai-saiko-to and Choto-san did not have such an effect. Moreover, Saiko-ka-ryukotsu-borei-to attenuated the heart rate. In Oren-gedoku-to, San'o-shashin-to and Dai-jyoki-to, a reduction in peripheral blood flow was observed. These results suggest that Saiko-ka-ryukotsuborei-to, Oren-gedoku-to, San'o-shashin-to and Dai-jyoki-to are ameliorative to the hypertension in sympathetic system dominance and Shinbu-to is occasionally dangerous to it.
我们研究了9种临床上用于治疗高血压的汉方药对麻醉大鼠的影响，这些大鼠因静脉注射茶碱（5mg/kg）导致动脉血压、心率和外周血流增加，而这种增加部分或完全由内源性儿茶酚胺介导。每种汉方药（1g/kg）经十二指肠给药。真武汤导致动脉血压严重紊乱。柴胡加龙骨牡蛎汤、黄连解毒汤、三奥散和大柴胡汤有降压作用，而八珍益母丸、五砂散、大柴胡汤和柱附汤则没有这种作用。此外，柴胡加龙骨牡蛎汤使心率减慢。在黄连解毒汤、三奥散和大柴胡汤中，观察到外周血流减少。这些结果表明，柴胡加龙骨牡蛎汤、黄连解毒汤、三奥散和大柴胡汤对交感神经系统占优势的高血压有改善作用，而真武汤偶尔对其有危险。
