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间歇性自我导尿中用于非接触式尿道导管的在用润滑剂的微生物污染

Microbial contamination of in-use lubricants for non-touch urethral catheters in intermittent self-catheterization.

作者信息

Oie S, Kamiya A, Seto T, Suga A, Naito K

机构信息

Department of Pharmacy, Yamaguchi University Hospital, Ube, Japan.

出版信息

Biol Pharm Bull. 2000 Jun;23(6):781-3. doi: 10.1248/bpb.23.781.

Abstract

There are no reports on microbial contamination of repeatedly used lubricant (84-87% glycerin containing 0.02% benzalkonium chloride) for non-touch urethral catheters in intermittent self-catheterization. In this work, we evaluated microbial contamination of in-use lubricant and its prevention. Between September and December, 1996, microbial contamination and water activity of in-use lubricants in sheathed and lubricated non-touch catheters connected to a tube used by 46 outpatients at our hospital was examined. Microbial contamination was detected at 5 to 2.6 x 10(8) colony-forming units (CFU)/ml in 14 (30.4%) of 46 samples. With higher water activity of the lubricant (a higher dilution rate of the lubricant with water), a higher concentration of microbial contamination was observed. In 3 (21.4%) of the 14 patients using contaminated lubricant, urine samples showed the same microbial species as those detected in the lubricant. To prevent microbial contamination of the lubricant, dilution of the lubricant with water, as a result of repeated use, should be avoided.

摘要

关于间歇性自我导尿术中反复使用的非接触式尿道导管润滑剂(含0.02%苯扎氯铵的84 - 87%甘油)的微生物污染情况尚无相关报道。在本研究中,我们评估了使用中的润滑剂的微生物污染情况及其预防措施。1996年9月至12月期间,对我院46名门诊患者使用的连接于鞘套及润滑的非接触式导管上的使用中的润滑剂的微生物污染及水分活性进行了检测。在46份样本中的14份(30.4%)中检测到微生物污染,污染程度为5至2.6×10⁸菌落形成单位(CFU)/毫升。润滑剂的水分活性越高(润滑剂与水的稀释率越高),观察到的微生物污染浓度越高。在使用受污染润滑剂的14名患者中的3名(21.4%)患者的尿液样本中,检测到与润滑剂中相同的微生物种类。为防止润滑剂受到微生物污染,应避免因反复使用导致润滑剂被水稀释。

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