Kita T, Kume N, Yokode M, Ishii K, Arai H, Horiuchi H, Moriwaki H, Minami M, Kataoka H, Wakatsuki Y
Graduate School of Medicine, Kyoto University, Department of Geriatric Medicine, Japan.
Ann N Y Acad Sci. 2000 May;902:95-100; discussion 100-2. doi: 10.1111/j.1749-6632.2000.tb06304.x.
The accumulation of substantial numbers of monocyte/macrophages and activated T lymphocytes in focal areas of the arterial intima appears to be a hallmark of atherosclerosis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherosclerotic lipoproteins, such as oxidized LDL and remnant lipoproteins in diabetic and Type 3 hyperlipidemia, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF A and B chains. Recently, we identified the novel receptor for oxidized LDL, named LOX-1. We summarize the importance of the interaction between oxidized LDL and its receptor, LOX-1, in terms of early stage atherogenesis.
动脉内膜局部区域大量单核细胞/巨噬细胞和活化T淋巴细胞的积聚似乎是动脉粥样硬化的一个标志。我们的报告表明，溶血磷脂酰胆碱（lyso-PC）是一种极性磷脂成分，在动脉粥样硬化脂蛋白（如糖尿病和Ⅲ型高脂血症中的氧化型低密度脂蛋白和残余脂蛋白）中含量增加，它可以上调单核细胞和T淋巴细胞的黏附分子以及生长因子，如肝素结合表皮生长因子样生长因子和血小板衍生生长因子A链和B链。最近，我们鉴定出了氧化型低密度脂蛋白的新型受体，命名为LOX-1。我们从动脉粥样硬化早期发生的角度总结了氧化型低密度脂蛋白与其受体LOX-1之间相互作用的重要性。
