Nierman W, Eisen J A, Fraser C M
The Institute for Genomic Research, Rockville, MD 20850, USA.
Res Microbiol. 2000 Mar;151(2):79-84.
The complete genome sequence has been reported for 24 microbial organisms. The genome organization and gene content of these organisms has revealed an incredible diversity. Nearly half of the open reading frames identified by these sequencing projects are for potential genes with no known biological function. Efforts to make evolutionary sense and biological sense of the gene content of these organisms have been initiated. The greatest future challenge of genomics will be to determine function for the unknown genes.
已报道了24种微生物的全基因组序列。这些生物体的基因组结构和基因组成显示出了令人难以置信的多样性。通过这些测序项目鉴定出的开放阅读框中，近一半是针对尚无已知生物学功能的潜在基因。人们已开始努力从进化意义和生物学意义上理解这些生物体的基因组成。基因组学未来最大的挑战将是确定未知基因的功能。
