Sampson Samantha L, Rengarajan Jyothi, Rubin Eric J
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Expert Rev Vaccines. 2003 Jun;2(3):437-45. doi: 10.1586/14760584.2.3.437.
Complete genome sequences are available for an increasing number of pathogenic bacteria. These new data are beginning to make an impact on the understanding of bacterial evolution and virulence. Thus far, however, vaccine development has had little benefit from genomics. Here we discuss how genomic sequence is being used in ways that could help identify useful bacterial antigens or create attenuated live vaccines.
越来越多致病细菌的全基因组序列已可获取。这些新数据开始对理解细菌进化和毒力产生影响。然而，到目前为止，疫苗开发从基因组学中获益甚少。在此，我们讨论基因组序列正以何种方式被用于帮助识别有用的细菌抗原或创制减毒活疫苗。
