3-[N-甲基-N-(3-甲基-1,3-噻唑-2-基)氨基]甲基头孢菌素衍生物的合成及其体外抗菌活性
Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives.
作者信息
Kim S H, Son H, Nam G, Chi D Y, Kim J H
机构信息
Biochemicals Research Center, Korea Institute of Science and Technology, Seoul, South Korea.
出版信息
Bioorg Med Chem Lett. 2000 Jun 5;10(11):1143-5. doi: 10.1016/s0960-894x(00)00130-x.
Abstract
The new cephalosporins having N-linked quarternary ammonium salt at C-3 position were prepared from the reaction of 2-methylimino-3-methyl-1,3-thiazoline derivatives with cephalosporins. Also antimicrobial activities of those compounds were determined.
摘要
通过2-甲基亚氨基-3-甲基-1,3-噻唑啉衍生物与头孢菌素的反应制备了在C-3位具有N-连接季铵盐的新型头孢菌素。还测定了这些化合物的抗菌活性。
相似文献
1
Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives.3-[N-甲基-N-(3-甲基-1,3-噻唑-2-基)氨基]甲基头孢菌素衍生物的合成及其体外抗菌活性
Bioorg Med Chem Lett. 2000 Jun 5;10(11):1143-5. doi: 10.1016/s0960-894x(00)00130-x.
2
Studies on beta-lactam antibiotics. I. Synthesis and in vitro anti-pseudomonal activity of 3-isothiazole-cephalosporin derivatives.β-内酰胺类抗生素的研究。I. 3-异噻唑头孢菌素衍生物的合成及其体外抗假单胞菌活性
J Antibiot (Tokyo). 1987 Feb;40(2):173-81. doi: 10.7164/antibiotics.40.173.
3
Synthesis and activity of 3-(isoxazolin-5-yl)- and 3-(isoxazol-4-yl)cephalosporins.3-（异恶唑啉-5-基）和3-（异恶唑-4-基）头孢菌素的合成与活性
J Antibiot (Tokyo). 1992 Dec;45(12):1930-8. doi: 10.7164/antibiotics.45.1930.
4
Synthesis and activity of potent 3-(isoxazolidin-5-yl)- and 3-(isoxazolidinium-5-yl)cephalosporins.强效3-（异恶唑烷-5-基）和3-（异恶唑烷鎓-5-基）头孢菌素的合成与活性
J Antibiot (Tokyo). 1992 Dec;45(12):1939-48. doi: 10.7164/antibiotics.45.1939.
5
Synthetic cephalosporins. VIII. Synthesis and antibacterial activity of CP6232, a new anti-pseudomonal cephalosporin.合成头孢菌素。VIII.新型抗铜绿假单胞菌头孢菌素CP6232的合成及抗菌活性
J Antibiot (Tokyo). 1992 Apr;45(4):595-8. doi: 10.7164/antibiotics.45.595.
6
Studies on condensed-heterocyclic azolium cephalosporins. III. Synthesis and antibacterial activity of 7 beta-[2-(2-amino-5-substituted-thiazol-4-yl)-2 (Z)-alkoxyiminoacetamido]-3-(condensed-heterocyclic azolium)methyl-3-cephem-4- carboxylates.稠合杂环唑鎓头孢菌素的研究。III. 7β-[2-(2-氨基-5-取代噻唑-4-基)-2(Z)-烷氧基亚氨基乙酰胺基]-3-(稠合杂环唑鎓)甲基-3-头孢烯-4-羧酸酯的合成与抗菌活性
J Antibiot (Tokyo). 1992 Apr;45(4):485-99. doi: 10.7164/antibiotics.45.485.
7
Novel cephalosporin derivatives possessing a bicyclic heterocycle at the 3-position. Part II: Synthesis and antibacterial activity of 3-(5-methylthiazolo[4,5-c]pyridinium-2-yl)-thiomethylcephalosporin derivatives and related compounds.在3-位具有双环杂环的新型头孢菌素衍生物。第二部分：3-(5-甲基噻唑并[4,5-c]吡啶-2-基)硫代甲基头孢菌素衍生物及相关化合物的合成与抗菌活性
Bioorg Med Chem. 1998 Sep;6(9):1641-53. doi: 10.1016/s0968-0896(98)00103-5.
8
Synthesis and antibacterial activities of 2-oxaisocephems.2-氧杂异头孢菌素的合成及其抗菌活性
Chem Pharm Bull (Tokyo). 1994 Oct;42(10):2084-9. doi: 10.1248/cpb.42.2084.
9
Synthesis and in vitro antibacterial activity of new aminothiazole-oximepiperidone cephalosporins.新型氨基噻唑肟基哌啶头孢菌素的合成及体外抗菌活性研究。
Bioorg Med Chem Lett. 2021 May 15;40:127928. doi: 10.1016/j.bmcl.2021.127928. Epub 2021 Mar 8.
10
Design, synthesis and antibacterial activities of a series of new 2-oxaisocephems.设计、合成及一系列新型 2-氧代异头孢烯类化合物的抗菌活性。
Bioorg Med Chem Lett. 2012 Aug 15;22(16):5293-6. doi: 10.1016/j.bmcl.2012.06.040. Epub 2012 Jun 23.
引用本文的文献
1
Retraction Note: Molecular docking simulation, drug-likeness assessment, and pharmacokinetic study of some cephalosporin analogues against a penicillin-binding protein of Salmonella typhimurium.撤稿说明：某些头孢菌素类似物针对鼠伤寒沙门氏菌青霉素结合蛋白的分子对接模拟、类药性评估及药代动力学研究。
J Antibiot (Tokyo). 2024 Feb;77(2):128. doi: 10.1038/s41429-023-00684-1.
2
A Facile Approach to the Synthesis of 3,4-Disubstituted-2-Aminothiazolium Derivatives through the Use of A "Volatilizable" Support.一种通过使用“可挥发”载体合成3,4-二取代-2-氨基噻唑鎓衍生物的简便方法。
Tetrahedron Lett. 2010 Oct 27;51(43):5637-5639. doi: 10.1016/j.tetlet.2010.08.026.
Zotero 插件