3-[N-甲基-N-(3-甲基-1,3-噻唑-2-基)氨基]甲基头孢菌素衍生物的合成及其体外抗菌活性
Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives.
作者信息
Kim S H, Son H, Nam G, Chi D Y, Kim J H
机构信息
Biochemicals Research Center, Korea Institute of Science and Technology, Seoul, South Korea.
出版信息
Bioorg Med Chem Lett. 2000 Jun 5;10(11):1143-5. doi: 10.1016/s0960-894x(00)00130-x.
Abstract
The new cephalosporins having N-linked quarternary ammonium salt at C-3 position were prepared from the reaction of 2-methylimino-3-methyl-1,3-thiazoline derivatives with cephalosporins. Also antimicrobial activities of those compounds were determined.
摘要
通过2-甲基亚氨基-3-甲基-1,3-噻唑啉衍生物与头孢菌素的反应制备了在C-3位具有N-连接季铵盐的新型头孢菌素。还测定了这些化合物的抗菌活性。
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