Birkeland S A, Løkkegaard H, Storm H H
Lancet. 2000 May 27;355(9218):1886-7. doi: 10.1016/s0140-6736(00)02298-4.
The increased risk of cancer in patients who have had kidney transplants has mainly been attributed to immunosuppressive therapy; however, the prior period of uraemia and dialysis has also been postulated as a cofactor. We analysed cancer risk retrospectively in a cohort of 4178 patients undergoing renal replacement therapy, of whom 3592 were treated with dialysis alone and 1821 later had transplants. We found that excess cancer risk in such patients occurred after transplantation and not during dialysis.
肾移植患者患癌风险增加主要归因于免疫抑制治疗；然而，尿毒症和透析的前期也被假定为一个辅助因素。我们对4178例接受肾脏替代治疗的患者进行了回顾性癌症风险分析，其中3592例仅接受透析治疗，1821例后来接受了移植。我们发现，此类患者的额外癌症风险出现在移植后而非透析期间。
