Ajmani R S, Metter E J, Jaykumar R, Ingram D K, Spangler E L, Abugo O O, Rifkind J M
National Institutes of Health, Gerontology Research Center, Laboratories of Cellular and Molecular Biology and Clinical Investigation, Baltimore, MD 21224, USA.
Neurobiol Aging. 2000 Mar-Apr;21(2):257-69. doi: 10.1016/s0197-4580(00)00118-4.
This study investigates the age associated changes in hemorheological properties and cerebral blood flow. Partial correlations indicate that part of the age-dependent decrease in flow velocities can be attributed to a hemorheological decrement resulting in part from enhanced oxidative stress in the aged. A possible link with Alzheimer's pathology is suggested by the augmented hemorheological impairment resulting from in vitro incubation of red cells with amyloids. These results suggest that in aging, oxidative stress as well as amyloids may influence the fluid properties of blood, resulting in a potential decrement in blood flow and oxygen delivery to the brain. Animal intervention studies further demonstrate that altered hemorheological properties of blood can actually influence cognitive function. The relationships shown to exist between hemorheology, blood flow, amyloids, oxidative stress, and cognitive function suggest that these factors may be one of the mechanisms operating in the complex etiology of Alzheimer's disease.
本研究调查了血液流变学特性和脑血流量与年龄相关的变化。偏相关性分析表明，流速随年龄增长而下降的部分原因可归因于血液流变学的衰退，这部分是由于老年人氧化应激增强所致。红细胞与淀粉样蛋白体外孵育导致血液流变学损伤加剧，提示其与阿尔茨海默病病理学可能存在联系。这些结果表明，在衰老过程中，氧化应激以及淀粉样蛋白可能会影响血液的流体性质，导致脑血流量和氧气输送量潜在下降。动物干预研究进一步表明，血液流变学特性的改变实际上会影响认知功能。血液流变学、血流量、淀粉样蛋白、氧化应激和认知功能之间存在的关系表明，这些因素可能是阿尔茨海默病复杂病因中的作用机制之一。
