Haglund U, Abe T, Ahrén C, Braide I, Lundgren O
Eur Surg Res. 1976;8(5):448-60. doi: 10.1159/000127889.
The relationship between the mucosal lesions in the gut, observed after a 2-hour period of regional hypotension, and the blood pressure fall seen after the hypotensive period was investigated in cats. Untreated controls were compared to animals treated with intraluminal perfusion with nitrogenated or oxygenated saline or treated with intraluminal instillation of albumin, activated charcoal or aprotinin or i.v. injections of methylprednisolone. Untreated controls and cats perfused with nitrogenated saline exhibited a pronounced reduction in arterial blood pressure during the first posthypotensive hour. In the animals treated with methylprednisolone or perfused intraluminally with oxygenated saline only a small fall of blood pressure was observed. In the remaining groups of animals a moderate blood pressure reduction was noted. These results suggest a causal relationship between the intestinal mucosal damage and the posthypotensive cardiovascular derangement possibly via the release of cardiotoxic material from the hypoxic intestinal villi.
在猫身上研究了局部低血压2小时后观察到的肠道黏膜损伤与低血压期后血压下降之间的关系。将未治疗的对照组与接受腔内灌注含氮或含氧生理盐水、腔内滴注白蛋白、活性炭或抑肽酶治疗的动物，或静脉注射甲基泼尼松龙治疗的动物进行比较。未治疗的对照组和用含氮生理盐水灌注的猫在低血压后的第一个小时动脉血压明显降低。在用甲基泼尼松龙治疗或仅用含氧生理盐水进行腔内灌注的动物中，仅观察到血压有小幅下降。在其余几组动物中，血压有中度降低。这些结果表明，肠道黏膜损伤与低血压后心血管紊乱之间可能存在因果关系，可能是通过缺氧肠绒毛释放心脏毒性物质所致。
