Haglund U, Lundholm K, Lundgren O, Scherstén T
Circ Shock. 1977;4(1):27-34.
A 2 hr-period of regional intestinal simulated shock in cats results in small intestinal mucosal lesions and a general cardiovascular derangement, probably secondary to the release of cardiotoxic material into the intestinal venous blood. These phenomenona are accompanied by release of lysosomal and cytoplasmatic enzymes from the intestinal tissue. The effects of methylprednisolone treatment and deposition of albumin in the intestinal lumen during the regional shock period were studied. Administration of methylprednisolone early and late in the regional shock period prevented mucosal lesions and cardiovascular deterioration as well as lysosomal and cytoplasmatic enzyme release. Albumin deposition in the intestinal lumen during the regional shock period prevented lysosomal enzyme release and cardiovascular derangement and to a minor extent mucosal lesions. It is suggested that release of intestinal lysosomal enzymes is of importance for development of mucosal lesions and for production of cardiotoxic material.
猫肠道局部模拟休克2小时会导致小肠黏膜损伤和全身性心血管紊乱，这可能继发于心毒性物质释放至肠道静脉血中。这些现象伴随着肠道组织中溶酶体酶和细胞质酶的释放。研究了甲基强的松龙治疗以及在局部休克期向肠腔内注入白蛋白的作用。在局部休克期的早期和晚期给予甲基强的松龙可预防黏膜损伤、心血管功能恶化以及溶酶体酶和细胞质酶的释放。在局部休克期向肠腔内注入白蛋白可预防溶酶体酶的释放和心血管紊乱，并在一定程度上预防黏膜损伤。提示肠道溶酶体酶的释放对黏膜损伤的发展及心毒性物质的产生具有重要作用。
