Shadrina M I, Kapylov V M, Miloserdova O V, Slominskiĭ P A, Limborskaia S A
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Genetika. 2000 May;36(5):718-20.
Chemokine receptors have recently been shown to mediate HIV-1 entry into cells. The chemokine receptor CCR5 plays a key role in this process. A 32-bp deletion within the coding region of the CCR5 gene generates a truncated nonfunctional receptor. In HIV-1-infected individuals homozygous for this mutation, disease progression is inhibited. We analyzed the frequencies of the deletion in HIV-1-infected seropositive individuals. No significant differences in allelic frequencies of the CCR5 gene between the control and general HIV-1-infected cohorts and within the latter group between the infected individuals and patients with AIDS symptoms were revealed.
最近研究表明，趋化因子受体介导HIV-1进入细胞。趋化因子受体CCR5在此过程中起关键作用。CCR5基因编码区内一个32bp的缺失产生截短的无功能受体。在该突变纯合的HIV-1感染个体中，疾病进展受到抑制。我们分析了HIV-1感染的血清阳性个体中该缺失的频率。在对照组和一般HIV-1感染队列之间以及在后者组内感染个体与有AIDS症状的患者之间，CCR5基因的等位基因频率均未显示出显著差异。
