Liapina L A, Kondashevskaia M V, Ziadetdinova G A, Uspenskaia M S
Moscow State University, Vorob'evy gory, Russia.
Izv Akad Nauk Ser Biol. 2000 May-Jun(3):345-9.
We have established that extracts prepared from various parts of the root of Paeonia anomala (bark and wood) have anticoagulant activity as indicated by the criterion of longer recalcification time of the normal rat blood plasma. This anticoagulant activity is due to the presence of heparin-like fragments in the preparations, which follows from the results of biochemical analysis and results of studies on the functional state of the mast cell population. Preparations from the peony root bark retain their anticoagulant properties in the circulatory system for 1.5 h after intravenous administration, similarly to heparin of the animal origin.
我们已经确定，以正常大鼠血浆再钙化时间延长为标准，从块根芍药（根皮和木质部）各部位制备的提取物具有抗凝活性。这种抗凝活性是由于制剂中存在类肝素片段，这是生化分析结果以及对肥大细胞群体功能状态研究结果得出的结论。芍药根皮制剂静脉给药后，在循环系统中的抗凝特性可保持1.5小时，这与动物源肝素类似。
