Ulvestad E
Avdeling for mikrobiologi og immunologi, Gades Institutt, Haukeland Sykehus, Bergen.
Tidsskr Nor Laegeforen. 2000 Apr 30;120(11):1317-22.
The role of HLA-B27 in rheumatic disease is reviewed.
The PubMed database was searched for the code words HLA-B27, ankylosing spondylitis, or their combinations. The diagnostic value of HLA-B27 for ankylosing spondylitis was calculated using Bayes' theorem.
It is still not clear whether HLA-B27 is a contributing causal factor for ankylosing spondylitis and reactive arthritis. Knowledge of a patient's HLA-B27 status for establishing prognostic information is of uncertain clinical value.
Knowledge of HLA-B27 status has limited diagnostic value. HLA-B27 status is clinically most informative when the test result is negative, as ankylosing spondylitis can be ruled out.
回顾了人类白细胞抗原B27（HLA - B27）在风湿性疾病中的作用。
在PubMed数据库中搜索关键词HLA - B27、强直性脊柱炎或它们的组合。使用贝叶斯定理计算HLA - B27对强直性脊柱炎的诊断价值。
HLA - B27是否为强直性脊柱炎和反应性关节炎的致病因素仍不清楚。了解患者的HLA - B27状态以建立预后信息的临床价值尚不确定。
HLA - B27状态的诊断价值有限。当检测结果为阴性时，HLA - B27状态在临床上最具信息价值，因为可以排除强直性脊柱炎。
