Ljungman P
Department of Hematology, Huddinge University Hospital, Karolinska Institute, Sweden.
Am J Med. 1997 Mar 17;102(3A):44-7. doi: 10.1016/s0002-9343(97)00010-7.
The role of respiratory viruses in severe complications following bone marrow transplantation was examined in a survey of selected transplant centers in Europe belonging to the European Group for Blood and Marrow Transplantation. Information was collected on 57 cases of infections with respiratory viruses, including adenoviruses. In two centers that had conducted prospective studies of bone marrow recipients with respiratory symptoms, the frequency of these infections was 7.1% and 4%, respectively. The severity of these infections varied. Pneumonias caused by respiratory syncytial virus and adenovirus were associated with mortality rates of 60% and 75%, respectively, whereas pneumonia caused by parainfluenza had a mortality rate of 20%. Influenza infections progressed to fatal pneumonia in 17% of cases. Results of antiviral therapy varied. As the results of our survey showed, respiratory virus infections are not infrequent after bone marrow transplantation and are associated with significant morbidity and mortality.
欧洲血液与骨髓移植组对欧洲部分移植中心进行了一项调查，以研究呼吸道病毒在骨髓移植后严重并发症中所起的作用。收集了57例呼吸道病毒感染病例的信息，其中包括腺病毒感染病例。在两个对有呼吸道症状的骨髓移植受者进行前瞻性研究的中心，这些感染的发生率分别为7.1%和4%。这些感染的严重程度各不相同。呼吸道合胞病毒和腺病毒引起的肺炎死亡率分别为60%和75%，而副流感病毒引起的肺炎死亡率为20%。17%的流感感染进展为致命性肺炎。抗病毒治疗的结果各不相同。正如我们的调查结果所示，骨髓移植后呼吸道病毒感染并不罕见，且与显著的发病率和死亡率相关。
