Roghmann M, Ball K, Erdman D, Lovchik J, Anderson L J, Edelman R
Epidemiology Section, Medical Care Clinical Center, VA Maryland Health Care System, Division of Healthcare Outcomes Research, Department of Epidemiology and Preventive Medicine, Baltimore, Maryland, USA.
Bone Marrow Transplant. 2003 Dec;32(11):1085-8. doi: 10.1038/sj.bmt.1704257.
Community-acquired respiratory virus (RV) infections are an important cause of disease in immunocompromised adults with cancer. To investigate the viral etiology, incidence, clinical presentation, and outcome of RV infections in an outpatient cohort of adult bone marrow or peripheral blood stem cell transplant (SCT) recipients, we monitored 62 outpatient volunteers from January 1 to April 30, 2001. A nasopharyngeal aspirate was collected from subjects when they reported new respiratory symptoms and tested for RV (influenza A, influenza B, human parainfluenza 1-3, adenovirus, and respiratory syncytial virus) by culture and reverse transcription polymerase chain reaction (RT-PCR) assay. Of 62 subjects enrolled, 27% had received allogeneic SCT and 45% were within 1 year of their transplant. In all, 35 participants (56%) reported 37 episodes of respiratory symptoms. Of the 37 specimens tested, five (14%) were positive for RV by culture and 20 (54%) were positive by RT-PCR. Only six patients with RV infections developed lower respiratory tract illnesses; these patients had received either autologous or allogeneic transplants and developed illnesses between 41 and 2666 days post transplant. Although RV infections were common in SCT outpatients during the RV season, most participants had upper respiratory tract infections, which resolved without the need for hospitalization.
社区获得性呼吸道病毒（RV）感染是免疫功能低下的成年癌症患者发病的重要原因。为了调查成年骨髓或外周血干细胞移植（SCT）受者门诊队列中RV感染的病毒病因、发病率、临床表现和结局，我们在2001年1月1日至4月30日期间对62名门诊志愿者进行了监测。当受试者报告出现新的呼吸道症状时，采集鼻咽抽吸物，并通过培养和逆转录聚合酶链反应（RT-PCR）检测RV（甲型流感病毒、乙型流感病毒、人副流感病毒1-3型、腺病毒和呼吸道合胞病毒）。在纳入的62名受试者中，27%接受了异基因SCT，45%在移植后1年内。共有35名参与者（56%）报告了37次呼吸道症状发作。在检测的37份标本中，5份（14%）培养出RV阳性，20份（54%）RT-PCR检测呈阳性。只有6名RV感染患者发展为下呼吸道疾病；这些患者接受了自体或异基因移植，在移植后41至2666天发病。尽管在RV流行季节，RV感染在SCT门诊患者中很常见，但大多数参与者患有上呼吸道感染，无需住院即可痊愈。
