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照射对受屏蔽骨髓造血干细胞的远隔效应——迁移的作用。

Abscopal effect of irradiation on haemopoietic stem cells of shielded bone marrow--role of migration.

作者信息

Croizat H, Frindel E, Tubiana M

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Oct;30(4):347-58. doi: 10.1080/09553007614551121.

DOI:10.1080/09553007614551121
PMID:1086846
Abstract

Immediately after partial-body irradiation, the number of colony-forming units (CFU) of the protected marrow decreases. This decrease seems to be dose-dependent and cannot be completely explained by migration for the following reasons: there is no evidence of CFU entry to irradiated territories and the number of circulating CFU does not increase. A more plausible explanation for the phenomena is an accelerated differentiation during the first 15 min after irradiation. The migration of CFU to the spleen is observed between 15 min and 3 hours after irradiation, after which it ceases. The absence of migration 3 hours after irradiation may be due to one of the two possibilities: (1) a depletion of the mobile pool of CFU if one admits that such a pool is responsible for migration in the organism; (2) a depletion of a temporarily increased stimulus due to irradiation.

摘要

局部身体照射后,受保护骨髓的集落形成单位(CFU)数量立即减少。这种减少似乎呈剂量依赖性,且由于以下原因不能完全用迁移来解释:没有证据表明CFU进入受照射区域,并且循环CFU的数量没有增加。对该现象更合理的解释是照射后最初15分钟内分化加速。照射后15分钟至3小时可观察到CFU向脾脏迁移,之后迁移停止。照射3小时后迁移停止可能是由于以下两种可能性之一:(1)如果认为这样一个池负责在生物体中的迁移,则CFU的可移动池耗尽;(2)由于照射导致暂时增加的刺激耗尽。

相似文献

1
Abscopal effect of irradiation on haemopoietic stem cells of shielded bone marrow--role of migration.照射对受屏蔽骨髓造血干细胞的远隔效应——迁移的作用。
Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Oct;30(4):347-58. doi: 10.1080/09553007614551121.
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The effect of partial body irradiation on haemopoietic stem cell migration.
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Radioprotection of mice with interleukin-1: relationship to the number of spleen colony-forming units.白细胞介素-1对小鼠的辐射防护作用:与脾集落形成单位数量的关系
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[Restoration of the quantity of colony forming units in the bone marrow and spleen of irradiated mice treated with DNA].[用DNA处理的受辐照小鼠骨髓和脾脏中集落形成单位数量的恢复]
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Control of B-cell maturation in mice. I. Increased B-cell maturation in vitro by bone marrow protected during whole body irradiation.小鼠B细胞成熟的调控。I. 全身照射期间受保护的骨髓在体外促进B细胞成熟。
Immunology. 1981 Feb;42(2):267-76.