Croizat H, Frindel E, Tubiana M
Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Oct;30(4):347-58. doi: 10.1080/09553007614551121.
Immediately after partial-body irradiation, the number of colony-forming units (CFU) of the protected marrow decreases. This decrease seems to be dose-dependent and cannot be completely explained by migration for the following reasons: there is no evidence of CFU entry to irradiated territories and the number of circulating CFU does not increase. A more plausible explanation for the phenomena is an accelerated differentiation during the first 15 min after irradiation. The migration of CFU to the spleen is observed between 15 min and 3 hours after irradiation, after which it ceases. The absence of migration 3 hours after irradiation may be due to one of the two possibilities: (1) a depletion of the mobile pool of CFU if one admits that such a pool is responsible for migration in the organism; (2) a depletion of a temporarily increased stimulus due to irradiation.
局部身体照射后,受保护骨髓的集落形成单位(CFU)数量立即减少。这种减少似乎呈剂量依赖性,且由于以下原因不能完全用迁移来解释:没有证据表明CFU进入受照射区域,并且循环CFU的数量没有增加。对该现象更合理的解释是照射后最初15分钟内分化加速。照射后15分钟至3小时可观察到CFU向脾脏迁移,之后迁移停止。照射3小时后迁移停止可能是由于以下两种可能性之一:(1)如果认为这样一个池负责在生物体中的迁移,则CFU的可移动池耗尽;(2)由于照射导致暂时增加的刺激耗尽。