Schiml P A, Rissman E F
Department of Biology, University of Virginia, Charlottesville 22903, USA.
Horm Behav. 2000 May;37(3):212-20. doi: 10.1006/hbeh.2000.1575.
The effects of intracerebroventricular (icv) infusion of four neuropeptides on female sexual behavior were examined in the female musk shrew (Suncus murinus). In the first experiment, (icv) infusion of 100 ng of the mammalian form of gonadotropin-releasing hormone (mGnRH) facilitated rapid display of receptivity. Gonadotropin-releasing hormone-infused females had shorter latencies to rump present and tail wag, compared with controls. In a second experiment, icv administration of the other form of GnRH present in musk shrew brain, the chicken GnRH-II form, produced no changes in female behavior relative to the control condition. In Experiment 3, icv delivery of corticotropin-releasing hormone (CRH) facilitated female sexual behavior, relative to vasopressin and controls. The females treated with CRH had shorter latencies to display rump present, tail wag, and for the receipt of the first missed intromission compared with females in the other treatment groups. Vasopressin increased female scent marking relative to that of CRH-treated females. These data indicate that neurohormones of the hypothalamic-pituitary-gonadal and the hypothalamic-pituitary-adrenal axes can facilitate reproductive behavior in S. murinus.
在雌性麝鼩（Suncus murinus）中研究了脑室内（icv）注射四种神经肽对其性行为的影响。在第一个实验中，脑室内注射100 ng的哺乳动物形式促性腺激素释放激素（mGnRH）可促进快速出现接受性行为的表现。与对照组相比，注射促性腺激素释放激素的雌性出现臀部抬起和尾巴摆动的潜伏期更短。在第二个实验中，脑室内注射麝鼩脑中存在的另一种形式的GnRH，即鸡GnRH-II，与对照条件相比，雌性行为没有变化。在实验3中，与加压素和对照组相比，脑室内注射促肾上腺皮质激素释放激素（CRH）促进了雌性性行为。与其他治疗组的雌性相比，接受CRH治疗的雌性出现臀部抬起、尾巴摆动以及首次错过插入的潜伏期更短。与接受CRH治疗的雌性相比，加压素增加了雌性的气味标记。这些数据表明，下丘脑-垂体-性腺轴和下丘脑-垂体-肾上腺轴的神经激素可以促进麝鼩的生殖行为。
