Ramesh V, Mohan Kumar V
Department of Physiology, All India Institute of Medical Sciences, 110 029, New Delhi, India.
Neuroscience. 2000;98(3):549-53. doi: 10.1016/s0306-4522(00)00128-7.
This study was undertaken to assess the role of catecholamine fibers, terminating in the preoptic area, in regulating sleep-wakefulness in rats. Sleep-wakefulness was assessed on the basis of 24h electroencephalogram, electromyogram and electro-oculogram recordings before and after destruction of catecholaminergic terminals at the medial preoptic area by bilateral intracerebral injection of 6-hydroxydopamine (8 microg in 0.2 microl). There was a mild reduction in sleep and increase in wakefulness after the lesion. The increase in active wakefulness observed after eight days of lesion persisted even on the 12th day. In spite of the reduction in sleep, the day-night sleep ratio was not affected by 6-hydroxydopamine lesion of the preoptic area. The results indicate that the noradrenergic fibers at the preoptic area have a hypnogenic role.
本研究旨在评估终止于视前区的儿茶酚胺能纤维在调节大鼠睡眠-觉醒中的作用。通过双侧脑室内注射6-羟基多巴胺（8微克/0.2微升）破坏视前内侧区的儿茶酚胺能终末之前和之后，根据24小时脑电图、肌电图和眼电图记录评估睡眠-觉醒情况。损伤后睡眠略有减少，觉醒增加。损伤八天后观察到的主动觉醒增加在第12天仍然存在。尽管睡眠减少，但视前区6-羟基多巴胺损伤并未影响昼夜睡眠比例。结果表明，视前区的去甲肾上腺素能纤维具有促眠作用。
