Sood S, Dhawan J K, Ramesh V, John J, Gopinath G, Kumar V M
Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):1-5. doi: 10.1016/s0091-3057(96)00384-x.
The role of the medial preoptic area (mPOA) beta adrenergic receptors in the regulation of sleep-wakefulness (S-W) was investigated in this study. S-W was assessed on the basis of polygraphic recording of EEG, EMG and EOG in free moving rats. Intracerebral microinjection of beta agonist, isoproterenol, into the mPOA produced arousal. The study was also conducted on another set of rats in which noradrenergic (NE) innervation to the mPOA was destroyed by injecting 6-hydroxydopamine into the ventral noradrenergic bundle, in the brain stem. Local application of isoproterenol, into the mPOA, in these animals, did not produce any significant change in S-W. Thus, the increase in awake period obtained on isoproterenol administration was the result of its action on the presynaptic NE terminals. Possible involvement of other responses in the isoproterenol induced increase in wakefulness, is discussed.
本研究探讨了内侧视前区（mPOA）β肾上腺素能受体在睡眠-觉醒（S-W）调节中的作用。基于对自由活动大鼠脑电图（EEG）、肌电图（EMG）和眼电图（EOG）的多导记录来评估S-W。向mPOA脑内微量注射β激动剂异丙肾上腺素可引起觉醒。还对另一组大鼠进行了研究，通过向脑干腹侧去甲肾上腺素能束注射6-羟基多巴胺来破坏mPOA的去甲肾上腺素能（NE）神经支配。在这些动物中，向mPOA局部应用异丙肾上腺素，S-W未产生任何显著变化。因此，给予异丙肾上腺素后清醒期的增加是其对突触前NE终末作用的结果。文中讨论了异丙肾上腺素诱导觉醒增加过程中其他反应可能的参与情况。
