Safety and tolerability of gamma-hydroxybutyric acid in the treatment of alcohol-dependent patients.
作者信息
Beghè F, Carpanini M T
机构信息
Clinical and Pharmacological Research Unit "Piertomaso Tessitore" and Pharmaco-surveillance Department, Laboratorio Farmaceutico C.T., Via Dante Alighieri 71, 18038, Sanremo, Italy.
出版信息
Alcohol. 2000 Apr;20(3):223-5. doi: 10.1016/s0741-8329(99)00085-3.
Gamma-hydroxybutyric acid (GHB) has been in clinical use in Italy since 1991 for treatment of alcohol dependence. Results of phase III and phase IV studies have shown that the drug is effective and well tolerated in the treatment of alcohol withdrawal syndrome and in reducing alcohol consumption and alcohol craving. Pharmacosurveillance indicates that abuse of gamma-hydroxybutyric acid is a limited phenomenon in clinical settings when the drug is dispensed under strict medical surveillance and entrusted to a referring familiar member of the patient.
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