Smith R C, Strong J R, Hicks P B, Samorajski T
Psychopharmacology (Berl). 1979 Feb 28;60(3):241-6. doi: 10.1007/BF00426662.
Behavioral evidence for tolerance and supersensitivity during and after chronic (30 day) administration of bromocriptine (BRC) or bromocriptine + L-dopa in mice was assessed by measuring wheel running (WR) behavior during and after chronic drug administration, and apomorphine- and methylphenidate-(MP-)induced stereotyped gnawing after termination of chronic injections. In both BRC and BRC + L-dopa groups, tolerance developed fairly quickly to the depressing effect of BRC on WR seen on day 1 of drug administration. Mice receiving BRC showed significant increases in WR by week 2 of chronic drug administration, which persisted for at least two days after the termination of chronic injections. During the first week after termination of chronic injections, low doses of both apomorphine and MP induced significantly more stereotyped gnawing in BRC and BRC + L-dopa mice than in the control mice or the mice treated with L-dopa alone. This behavioral evidence for dopaminergic supersensitivity after chronic BRC administration may have relevance for the clinical use of BRC in combination with L-dopa or other dopamine agonists.
通过测量慢性给药期间及之后的轮转行为（WR），以及慢性注射终止后阿扑吗啡和哌醋甲酯（MP）诱导的刻板啃咬行为，评估了小鼠在慢性（30天）给予溴隐亭（BRC）或溴隐亭+左旋多巴期间及之后耐受性和超敏反应的行为证据。在BRC组和BRC+左旋多巴组中，对给药第1天观察到的BRC对WR的抑制作用，耐受性发展相当迅速。接受BRC的小鼠在慢性给药第2周时WR显著增加，在慢性注射终止后至少持续两天。在慢性注射终止后的第一周内，低剂量的阿扑吗啡和MP在BRC组和BRC+左旋多巴组小鼠中诱导的刻板啃咬行为明显多于对照组小鼠或仅用左旋多巴治疗的小鼠。慢性给予BRC后这种多巴胺能超敏反应的行为证据可能与BRC与左旋多巴或其他多巴胺激动剂联合使用的临床应用有关。
