Sachinvala N, Kling A, Suffin S, Lake R, Cohen M
Sepulveda Veterans Affairs Medical Center, CA, USA.
Mil Med. 2000 Jun;165(6):473-9.
Because of the treatment resistance and chronic affective lability of many post-traumatic stress disorder (PTSD) patients and the hypothesized association of these behaviors with temporal and limbic structures, a study was conducted to determine whether these patients would exhibit alterations in regional cerebral perfusion in the temporal and limbic regions compared with age-matched normal volunteers at rest.
We studied 17 patients using 99mTc hexamethyl propylene amine oxime single photon emission computed tomography. Seven of the patients were on a selective serotonin reuptake inhibitor, five were on a tricyclic antidepressant, and five were on no medication at the time of the study. Patients were compared with eight age-matched normal controls.
All PTSD patients showed a relative increase in regional cerebral perfusion in the anterior and posterior cingulate regions bilaterally, the right temporal and parietal regions, the right caudate/putamen region, and the left orbital and hippocampal regions compared with the control group. When the group of PTSD patients who were free of medication were compared with the control group, increased regional cerebral perfusion was found in the right and left caudate/putamen regions and the right orbital and anterior cingulate cortex bilaterally.
PTSD is associated with increased regional blood flow in limbic areas and the right temporal and parietal cortex compared with age-matched normal volunteers.
由于许多创伤后应激障碍（PTSD）患者存在治疗抵抗和慢性情感不稳定，且这些行为与颞叶和边缘系统结构之间存在假设关联，因此开展了一项研究，以确定与年龄匹配的正常志愿者相比，这些患者在静息状态下颞叶和边缘区域的脑灌注是否会出现改变。
我们使用99mTc六甲基丙烯胺肟单光子发射计算机断层扫描对17例患者进行了研究。其中7例患者正在服用选择性5-羟色胺再摄取抑制剂，5例正在服用三环类抗抑郁药，5例在研究时未服用任何药物。将患者与8名年龄匹配的正常对照进行比较。
与对照组相比，所有PTSD患者双侧前扣带回和后扣带回区域、右侧颞叶和顶叶区域、右侧尾状核/壳核区域以及左侧眶部和海马区域的脑灌注均相对增加。当将未服用药物的PTSD患者组与对照组进行比较时，发现双侧右侧和左侧尾状核/壳核区域以及右侧眶部和前扣带回皮质的脑灌注增加。
与年龄匹配的正常志愿者相比，PTSD与边缘区域以及右侧颞叶和顶叶皮质的局部血流增加有关。
