Malashkhiia Iu A, Dugladze N A, Geladze M G
Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(10):1483-5.
By means of PHA-tests and rosette-formation the authors detected in the CSF of patients with serous meningitis T- and B-lymphocytes. They assume that in serous meningitis the penetration of alien antigens into the subarachnoidal space facilitates the migration of T- and B-lymphocytes into the CSF from the lymphoid organs and peripheral blood. On the grounds of these data the authors propose a new concept which assumes that besides the hematoenecephalic barrier, there is also an immunological brain barrier, the morphofunctional basis of which is the CSF with circulating T- and B-lymphocytes and immunoglobulins of different classes.
通过PHA试验和玫瑰花结形成试验,作者在浆液性脑膜炎患者的脑脊液中检测到了T淋巴细胞和B淋巴细胞。他们认为,在浆液性脑膜炎中,外来抗原进入蛛网膜下腔促使T淋巴细胞和B淋巴细胞从淋巴器官和外周血迁移至脑脊液中。基于这些数据,作者提出了一个新的概念,即除血脑屏障外,还存在一种免疫性脑屏障,其形态功能基础是含有循环T淋巴细胞、B淋巴细胞及不同类免疫球蛋白的脑脊液。