多发性硬化症的磁共振静脉成像
MR venography of multiple sclerosis.
作者信息
Tan I L, van Schijndel R A, Pouwels P J, van Walderveen M A, Reichenbach J R, Manoliu R A, Barkhof F
机构信息
Department of Radiology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
出版信息
AJNR Am J Neuroradiol. 2000 Jun-Jul;21(6):1039-42.
BACKGROUND AND PURPOSE
The distribution of multiple sclerosis (MS) lesions in the brain follows a specific pattern, with most lesions in the periventricular regions and in the deep white matter; histopathologic studies have shown a perivenous distribution. The aim of this study was to illustrate these distribution patterns in vivo using high-resolution MR venography.
METHODS
Seventeen MS patients underwent MR imaging at 1.5 T. Venographic studies were obtained with a 3D gradient-echo technique. MS lesions were identified on T2-weighted images, and their shape, orientation, and location were compared with the venous anatomy on the venograms.
RESULTS
The use of contrast material facilitated the visualization of small veins and increased the number of veins seen. A total of 95 MS lesions could be identified on both the T2-weighted series and the venograms; a central vein was visible in all 43 periventricular lesions and in all but one of the 52 focal deep white matter lesions. The typical ovoid shape and orientation of the long axis of the MS lesions correlated well with the course of these veins.
CONCLUSION
With MR venography, the perivenous distribution of MS lesions in the brain can be visualized in vivo. The venous anatomy defines the typical form and orientation of these lesions.
背景与目的
脑内多发性硬化（MS）病灶的分布遵循特定模式，大多数病灶位于脑室周围区域和深部白质；组织病理学研究显示病灶呈静脉周围分布。本研究的目的是利用高分辨率磁共振静脉成像在活体中显示这些分布模式。
方法
17例MS患者接受了1.5T磁共振成像检查。采用三维梯度回波技术进行静脉成像研究。在T2加权图像上识别MS病灶，并将其形状、方向和位置与静脉造影上的静脉解剖结构进行比较。
结果
使用对比剂有助于小静脉的可视化并增加了可见静脉的数量。在T2加权序列和静脉造影上共识别出95个MS病灶；在所有43个脑室周围病灶以及52个局灶性深部白质病灶中除1个外的所有病灶中均可见到中央静脉。MS病灶典型的卵圆形形状及其长轴方向与这些静脉的走行密切相关。
结论
通过磁共振静脉成像，可在活体中显示脑内MS病灶的静脉周围分布。静脉解剖结构决定了这些病灶的典型形态和方向。
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