[Effect of pantoprazole, amoxicillin and metronidazole treatment on the level of H. pylori eradication and the histological image of antral gastritis in patients with duodenal ulcer].

BACKGROUND

Relationships between Helicobacter pylori infection, inflammatory changes in antral region of gastric mucosa, and duodenal ulcer is well known and documented in a large number of studies. This trial is designed to examine effect of one week regimen of Pantoprazole, Amoxycillinum and Metronidazol to eradication of H. pylori, duodenal ulcer healing and histological changes on gastric mucosa.

PATIENTS AND METHODS

30 patients with active duodenal ulcer, H. pylori-positive, 16 male, with average age 47.12 +/- 13.13 yrs (AVG +/- STD) and 14 female patients with average age 44.47 +/- 12.29 yrs were included in trial. Biopsy of gastric antral region were performed in each patient. Patients were given Pantoprazole 40 mg bid, Amoxycillinum 1000 mg bid, Metronidazolum 500 mg bid for 7 days. After 7 days of treatment, control endoscopy was performed with repeated rapid ureasa test for H. pylori and antral biopsy and with verification of duodenal ulcer healing. Patients were followed up for 24.3 +/- 9.7 weeks for occasion of subjective symptoms.

RESULTS

96.67% patients were presented with eradicated H. pylori, complete ulcer healing was found in 83.34% patients after one week regimen (13.33% patients with ulcer reduced on one third of previous described), 73.33% of patients were presented with histologically feature of chronic gastritis turned from active to stationary phase.

CONCLUSION

One week regiment with Pantoprazole, Amoxycilline and Metronidazole is effective, and beside a high rate ulcer healing and eradication of H. pylori it provides an improvement of histological feature of antral gastritis.