Naor D, Bonavida B, Robinson R A, Shibata I N, Percy D E, Chia D, Barnett E V
Eur J Immunol. 1976 Nov;6(11):783-9. doi: 10.1002/eji.1830061106.
NZB and NZB/W mice have reduced anti-sheep red cell (SRC) and 2,4,6-trinitrophenyl-plaque-froming cell (TNP-PFC) responses with age after injection of either the thymus-dependent antigen TNP-SRC or the thymus-independent antigen TNP-mouse red cells (MRC). However, the thymus-dependent response diminished much faster than the thymus-independent response. As a consequence, young New Zealand mice have a higher anti-TNP response after injection of TNP-SRC than after injection of TNP-MRC, while old New Zealand mice have a higher anti-TNP response after injection of TNP-MRC than after injection of TNP-SRC. The PFC avidity of NZB/W mice injected with TNP-SRC diminished with age, while the PFC avidity of mice injected with TNP-MRC did not change with agrc or TNP-SRC. Old NZB/W mice had few spontaneous anti-MRC-PFC. The number of anti-MRC PFC in old mice was increased 4 to 10 times after injection with either TNP-SRC or TNP-MRC. It is suggested that surveillance mechanisms are responsible for suppressing the autoimmune response to modified self-antigens. The unregulated immune system of NZB and NZB/W mice appears to be an expression of impairment of such a hypothetical surveillance mechanism.
在注射胸腺依赖性抗原三硝基苯 - 绵羊红细胞（TNP - SRC）或胸腺非依赖性抗原三硝基苯 - 小鼠红细胞（TNP - MRC）后，NZB和NZB/W小鼠随着年龄增长，其抗绵羊红细胞（SRC）和2,4,6 - 三硝基苯 - 噬斑形成细胞（TNP - PFC）反应降低。然而，胸腺依赖性反应比胸腺非依赖性反应下降得快得多。因此，年轻的新西兰小鼠在注射TNP - SRC后比注射TNP - MRC后的抗TNP反应更高，而年老的新西兰小鼠在注射TNP - MRC后比注射TNP - SRC后的抗TNP反应更高。注射TNP - SRC的NZB/W小鼠的PFC亲和力随年龄降低，而注射TNP - MRC的小鼠的PFC亲和力不随年龄或TNP - SRC而变化。年老的NZB/W小鼠几乎没有自发的抗MRC - PFC。年老小鼠在注射TNP - SRC或TNP - MRC后，抗MRC PFC的数量增加了4到10倍。有人提出，监视机制负责抑制对修饰的自身抗原的自身免疫反应。NZB和NZB/W小鼠不受调控的免疫系统似乎是这种假设的监视机制受损的一种表现。
