Strang R, Damato F A, Creanor S L, Stephen K W
Department of Clinical Physics and Bioengineering, Glasgow, Scotland.
J Dent Res. 1987 Nov;66(11):1644-6. doi: 10.1177/00220345870660110801.
The effect of baseline lesion mineral loss on the remineralization of enamel lesions by a sodium fluoride dentifrice was studied in situ by means of an appliance carrying enamel sections. Artificial lesions of various sizes were created, by means of acidified gelatin, and were then mounted on the appliances of five volunteers. Each brushed twice daily for two min with a 1000 ppm F sodium fluoride dentifrice. Measurements of mineral content were made at baseline and at weekly intervals by microradiographic/microdensitometric techniques. Data from all five volunteers showed a linear increase in remineralization rate with increasing lesion size. Thus, in studies which compare the effects of different remineralizing formulations, care must be taken to ensure that initial lesion sizes are matched, or that the results are expressed as a percentage change in mineral content.
利用带有釉质切片的装置在原位研究了基线病变矿物质流失对含氟化钠牙膏使釉质病变再矿化的影响。通过酸化明胶制作了各种大小的人工病变，然后将其安装在五名志愿者的装置上。每位志愿者每天用含1000 ppm氟的氟化钠牙膏刷牙两次，每次两分钟。通过显微放射照相/显微密度测定技术在基线和每周进行矿物质含量测量。来自所有五名志愿者的数据显示，随着病变大小增加，再矿化速率呈线性增加。因此，在比较不同再矿化配方效果的研究中，必须注意确保初始病变大小匹配，或者结果以矿物质含量的百分比变化表示。
