Thiébot M H, Jobert A, Soubrié P
Psychopharmacology (Berl). 1979 Mar 14;61(1):85-9. doi: 10.1007/BF00426816.
Diazepam and muscimol, a direct GABA agonist, were compared on behavioral inhibition induced in rats by (1) novelty, (2) punishment, and (3) nonreward. (1) Muscimol (0.03--0.25 mg . kg-1 i.p. 30 min before testing, or i.v. immediately before testing) failed to enhance food intake consistently in a nonfamiliar situation and (0.125--0.5 mg . kg-1 i.p. or i.v.) to increase the ingestion of an unknown food (chocolate); (2) muscimol (0.125--0.5 mg . kg-1 i.p. or 0.25 i.v. 10 min before testing) was ineffective in reducing the inhibition of lever presses for food elicited by the delivery of an electric shock at every eighth press; (3) muscimol (0.125--0.5 mg . kg-1 i.p.) failed to attenuate the inhibitory effects on responding induced by the suppression of the reinforcement during extinction. Contrastingly, diazepam (2 mg . kg-1 i.p. 30 min before testing) was found to reduce each type of behavioral inhibition. These data lend no support to the hypotheses of GABA control of behavioral inhibition and of GABA involvement in the action of benzodiazepines on inhibition induced by novelty, punishment, or nonreward.
将地西泮与直接γ-氨基丁酸（GABA）激动剂蝇蕈醇进行了比较，观察它们对大鼠由以下三种情况诱导的行为抑制作用：（1）新奇感；（2）惩罚；（3）无奖赏。（1）蝇蕈醇（腹腔注射0.03 - 0.25毫克·千克⁻¹，在测试前30分钟给药，或静脉注射，在测试前即刻给药）未能在不熟悉的情境中持续增加食物摄入量，且（腹腔注射或静脉注射0.125 - 0.5毫克·千克⁻¹）未能增加对未知食物（巧克力）的摄取量；（2）蝇蕈醇（腹腔注射0.125 - 0.5毫克·千克⁻¹，或静脉注射0.25毫克·千克⁻¹，在测试前10分钟给药）对减少每第八次按压杠杆获取食物时因电击而引发的抑制作用无效；（3）蝇蕈醇（腹腔注射0.125 - 0.5毫克·千克⁻¹）未能减弱在消退过程中强化物抑制时对反应产生的抑制作用。相比之下，发现地西泮（腹腔注射2毫克·千克⁻¹，在测试前30分钟给药）可减少每种行为抑制类型。这些数据不支持关于GABA控制行为抑制以及GABA参与苯二氮䓬类药物对由新奇感、惩罚或无奖赏诱导的抑制作用的假说。
