Anderson D T, Fritz K L
Los Angeles County Department of Coroner, California 90033, USA.
J Anal Toxicol. 2000 May-Jun;24(4):300-4. doi: 10.1093/jat/24.4.300.
Quetiapine is a new antipsychotic drug that has been available in the United States since September 1997. It belongs to a new chemical class of drugs called the dibenzothiazepine derivatives and is easily detected with a basic drug screen. The Los Angeles County Department of Coroner Toxicology Laboratory has encountered quetiapine in seven postmortem cases. Tissue distributions were determined in each of the seven cases. The analysis of quetiapine from postmortem specimens consisted of an n-butylchloride basic extraction with presumptive identification and quantitation on a gas chromatograph-nitrogen-phosphorus detector. Linearity was achieved from 0.10 to 3.0 mg/L with a limit of quantitation of 0.10 mg/L. Confirmation of quetiapine was performed on a gas chromatograph-mass spectrometer by comparison with a pure analytical standard. The tissue distribution of quetiapine was as follows: heart blood present, but less than (+<) 0.10-49 mg/L (seven cases); femoral blood +< 0.10-1.4 mg/L (five cases); liver +< 0.10-112 mg/kg (five cases); spleen 4.0 mg/kg (one case); urine 0-3.0 mg/L (two cases); bile 0.60-7.5 mg/L (three cases); and gastric contents +< 0.01-18 mg total (five cases). To our knowledge, this is the first report of the presence of quetiapine in postmortem specimens.
喹硫平是一种新型抗精神病药物，自1997年9月起在美国上市。它属于一类名为二苯并噻氮䓬衍生物的新型化学药物，在基础药物筛查中很容易被检测到。洛杉矶县验尸官毒理学实验室在7例死后病例中发现了喹硫平。对这7例病例均进行了组织分布测定。对死后标本中喹硫平的分析包括用正丁基氯进行碱性萃取，并在气相色谱 - 氮磷检测器上进行推定鉴定和定量。在0.10至3.0 mg/L范围内实现了线性，定量限为0.10 mg/L。通过与纯分析标准品比较，在气相色谱 - 质谱仪上对喹硫平进行了确证。喹硫平的组织分布如下：心血中存在，但低于（+<）0.10 - 49 mg/L（7例）；股血+< 0.10 - 1.4 mg/L（5例）；肝脏+< 0.10 - 112 mg/kg（5例）；脾脏4.0 mg/kg（1例）；尿液0 - 3.0 mg/L（2例）；胆汁0.60 - 7.5 mg/L（3例）；胃内容物总量+< 0.01 - 18 mg（5例）。据我们所知，这是死后标本中存在喹硫平的首次报告。
