McIntyre Iain M
Forensic Toxicology Laboratory Manager, County of San Diego Medical Examiner's Office, 5570 Overland Ave., Suite 101, San Diego, CA, 92123, USA,
Forensic Sci Med Pathol. 2014 Mar;10(1):91-6. doi: 10.1007/s12024-013-9503-x. Epub 2013 Nov 7.
The liver to peripheral blood (L/P) ratio, based upon review of previously published works, was evaluated as a marker of postmortem redistribution (PMR). Literature supported the proposed model that drugs exhibiting an L/P ratio of less than 5 are prone to little or no PMR, while those with an L/P ratio greater than 20-30 have propensity for significant redistribution. Many antidepressants, including both tricyclic antidepressants and selective serotonin re-uptake inhibitors, were markedly differentiated from drugs previously verified to be free from, or exhibit little, PMR. The magnitude of the liver to blood concentrations also appeared to provide an advantage over the conventional central to peripheral blood ratio model of PMR by demonstrating a wide range of values (1.6-97) for interpretation of drugs' potential for, and variations in, redistribution.
基于对先前发表作品的回顾，评估肝血比（L/P）作为死后再分布（PMR）的标志物。文献支持了所提出的模型，即L/P比值小于5的药物很少或不会发生PMR，而L/P比值大于20 - 30的药物则有显著再分布的倾向。许多抗抑郁药，包括三环类抗抑郁药和选择性5-羟色胺再摄取抑制剂，与先前证实无PMR或PMR不明显的药物有显著差异。肝血浓度的大小似乎也比传统的中心血与外周血比值的PMR模型更具优势，因为它展示了广泛的值范围（1.6 - 97），可用于解释药物再分布的可能性和变化情况。
