Jousilahti P, Tuomilehto J, Vartiainen E, Eriksson J, Puska P
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.
Am J Epidemiol. 2000 Jun 1;151(11):1112-20. doi: 10.1093/oxfordjournals.aje.a010155.
The purpose of this study was to analyze the association of adult height with cause-specific and total mortality. The study included 31,199 men and women aged 25-64 years who participated in a risk factor survey in 1972, 1977, 1982, or 1987 in eastern Finland. The cohorts were followed until the end of 1994. The relation between height and mortality was assessed by using Cox proportional hazard models. The authors found that height was associated inversely with most of the measured risk factors and directly with socioeconomic status. For both genders, height was inversely associated with cardiovascular and total mortality; the age- and birth-cohort-adjusted risk ratios per 5 cm increase in height were 0.89 and 0.91 for men and 0.86 and 0.90 for women, respectively. The inverse association also remained after adjustment for the other known risk factors. For men, an independent inverse association also was found between height and mortality from chronic obstructive pulmonary disease and from violence and accidents. Cancer mortality was not associated with height. Thus, genetic factors, and environmental factors during the fetal period, childhood, and adolescence, which determine adult height, appear to be related to a person's health later in life.
本研究的目的是分析成人身高与特定病因死亡率和总死亡率之间的关联。该研究纳入了31199名年龄在25至64岁之间的男性和女性，他们于1972年、1977年、1982年或1987年在芬兰东部参加了一项风险因素调查。对这些队列进行随访直至1994年底。使用Cox比例风险模型评估身高与死亡率之间的关系。作者发现，身高与大多数测量的风险因素呈负相关，与社会经济地位呈正相关。对于男性和女性，身高与心血管疾病死亡率和总死亡率均呈负相关；身高每增加5厘米，经年龄和出生队列调整后的风险比，男性分别为0.89和0.91，女性分别为0.86和0.90。在对其他已知风险因素进行调整后，这种负相关仍然存在。对于男性，还发现身高与慢性阻塞性肺疾病、暴力和事故导致的死亡率之间存在独立的负相关。癌症死亡率与身高无关。因此，决定成人身高的遗传因素以及胎儿期、儿童期和青春期的环境因素，似乎与一个人晚年的健康状况有关。
