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体外有丝分裂活性人淋巴细胞释放的与β-LT类淋巴毒素相关的多种细胞溶解成分的鉴定。

Identification of multiple cytolytic components associated with the beta-LT class of lymphotoxins released by mitogen-activity human lymphocytes in vitro.

作者信息

Hiserodt J C, Fair D S, Granger G A

出版信息

J Immunol. 1976 Nov;117(5 Pt 1):1503-6.

PMID:1087315
Abstract

Cytotoxic activity (lymphotoxin (LT) associated with the 50,000 dalton beta-LT class of human lymphotoxins has been resolved into multiple components by chromatography on DEAE-cellulose or electrophoresis on polyacrylamide gels. The two components, termed beta-LT, and beta-LT2, are separable from the 90,000 m.w. alpha-LT, since neither component is neutralized by incubation with heterologous rabbit anti-alpha-LT antisera. However, the two components differ in their overall charge and relative heat stability with the betaLT1 component being more positively charged than the beat-LT2 molecule and extremely heat labile.

摘要

细胞毒性活性（与50,000道尔顿的人淋巴毒素β-LT类相关的淋巴毒素（LT）已通过在DEAE-纤维素上的色谱法或在聚丙烯酰胺凝胶上的电泳分离成多个组分。这两个组分，称为β-LT1和β-LT2，可与90,000分子量的α-LT分离，因为与异源兔抗α-LT抗血清孵育均不能中和这两个组分。然而，这两个组分在总电荷和相对热稳定性方面存在差异，β-LT1组分比β-LT2分子带更多正电荷且极其热不稳定。

相似文献

1
Identification of multiple cytolytic components associated with the beta-LT class of lymphotoxins released by mitogen-activity human lymphocytes in vitro.体外有丝分裂活性人淋巴细胞释放的与β-LT类淋巴毒素相关的多种细胞溶解成分的鉴定。
J Immunol. 1976 Nov;117(5 Pt 1):1503-6.
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Cytotoxic activity of lymphocytes. VI. Heterogeneity of cytotoxins in supernatants of mitogen-activated lymphocytes.淋巴细胞的细胞毒性活性。VI. 有丝分裂原激活淋巴细胞上清液中细胞毒素的异质性。
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引用本文的文献

1
Effect of soluble products from lectin-stimulated lymphocytes on the growth, adhesiveness, and glycosaminoglycan synthesis of cultured synovial fibroblastic cells.凝集素刺激淋巴细胞产生的可溶性产物对培养的滑膜成纤维细胞生长、黏附及糖胺聚糖合成的影响。
J Clin Invest. 1981 Sep;68(3):792-802. doi: 10.1172/jci110316.
2
Production of mouse lymphotoxin by phytohemagglutinin-stimulated spleen cells requires two cell fractions.用植物血凝素刺激的脾细胞产生小鼠淋巴毒素需要两种细胞组分。
Infect Immun. 1982 Jun;36(3):1028-35. doi: 10.1128/iai.36.3.1028-1035.1982.