Dietz M, Furmanski P, Clymer R, Rich M A
J Natl Cancer Inst. 1976 Jul;57(1):91-5. doi: 10.1093/jnci/57.1.91.
To evaluate the role of immune response in regression of leukemia, we studied the effect of immunosuppression on the spontaneous regression of a leukemia induced by a specific strain of Friend murine leukemia virus complex (RFV). Thymectomy of newborn but not adult outbred Swiss mice markedly inhibited regression. The effect of antithymocyte serum (ATS) on regression depended on the timing of ATS treatment. Regression was markedly inhibited in leukemic mice given ATS just before the start of regression. During leukemia development, ATS treatment but not thymectomy potentiated splenomegaly and delayed the start of regression. Both ATS treatment and neonatal thymectomy increased mortality as a function of the decrease in disease regression. Treatment with normal rabbit serum also inhibited regression but, when given during leukemia development, affected neither the splenomegalic response to RFV nor the number of deaths. The data demonstrated that an intact immune system was required for leukemia regression and suggested that some thymus-dependent parameter of immune response was a major factor in regression.
为了评估免疫反应在白血病消退中的作用，我们研究了免疫抑制对由特定品系的弗氏鼠白血病病毒复合物（RFV）诱导的白血病自发消退的影响。新生而非成年的远交系瑞士小鼠进行胸腺切除显著抑制了白血病的消退。抗胸腺细胞血清（ATS）对白血病消退的影响取决于ATS治疗的时间。在白血病开始消退前给予ATS的白血病小鼠，其消退明显受到抑制。在白血病发展过程中，ATS治疗而非胸腺切除会使脾肿大加剧，并延迟消退的开始。ATS治疗和新生期胸腺切除均随着疾病消退的减少而增加死亡率。用正常兔血清治疗也会抑制消退，但在白血病发展过程中给予时，既不影响对RFV的脾肿大反应，也不影响死亡数量。数据表明，白血病消退需要完整的免疫系统，并提示免疫反应中某些依赖胸腺的参数是消退的主要因素。
