Longley C, Furmanski P
Leuk Res. 1982;6(5):703-10. doi: 10.1016/0145-2126(82)90087-x.
The role of complement was examined in the immunologically-mediated spontaneous regression of erythroleukemia induced by the RFV strain of the Friend virus complex. Hemolytic complement levels were not significantly altered during the leukemic, regressed and recurrent phases of the disease. No correlation was observed between leukemia regression and complement levels in normal, C5-deficient and hybrid mice. No correlation was observed between serum complement activity and leukemia recurrence or mortality due to leukemia. The data suggest that hemolytic complement, and thus those immune effector functions specifically dependent on full complement activity, are not involved in leukemia regression and do not influence the course of the disease.
在由Friend病毒复合体的RFV株诱导的红白血病免疫介导的自发消退过程中，对补体的作用进行了研究。在疾病的白血病期、消退期和复发期，溶血补体水平没有显著变化。在正常小鼠、C5缺陷小鼠和杂种小鼠中，未观察到白血病消退与补体水平之间的相关性。未观察到血清补体活性与白血病复发或白血病死亡率之间的相关性。数据表明，溶血补体以及因此那些特别依赖于完整补体活性的免疫效应功能，不参与白血病的消退，也不影响疾病的进程。
