苯妥英及其代谢产物5-（4-羟基苯基）-5-苯基乙内酰脲在培养的新生小鼠颅骨中显示出骨吸收作用。
Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria.
作者信息
Takahashi A, Onodera K, Shinoda H, Mayanagi H
机构信息
Department of Pharmacology, Tohoku University School of Dentistry, Sendai, Japan.
出版信息
Jpn J Pharmacol. 2000 Jan;82(1):82-4. doi: 10.1254/jjp.82.82.
PMID:10874595
Abstract
The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.
摘要
在体外研究了苯妥英及其主要代谢产物5-(4-羟苯基)-5-苯基乙内酰脲（HPPH）对新生小鼠颅骨骨吸收的影响。与培养72小时后的对照组相比，苯妥英和HPPH均诱导了显著的骨吸收。这种作用可能是苯妥英在体内引起骨质流失的原因。
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