Ko Ara, Kong Juhyun, Samadov Furkat, Mukhamedov Akmal, Kim Young Mi, Lee Yun-Jin, Nam Sang Ook
Division of Pediatric Neurology, Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Ann Pediatr Endocrinol Metab. 2020 Mar;25(1):15-23. doi: 10.6065/apem.2020.25.1.15. Epub 2020 Mar 31.
Patients with neurological disorders are at high risk of developing osteoporosis, as they possess multiple risk factors leading to low bone mineral density. Such factors include inactivity, decreased exposure to sunlight, poor nutrition, and the use of medication or treatment that can cause lower bone mineral density such as antiepileptic drugs, ketogenic diet, and glucocorticoids. In this article, mechanisms involved in altered bone health in children with neurological disorders and management for patients with epilepsy, cerebral palsy, and Duchenne muscular dystrophy regarding bone health are reviewed.
患有神经系统疾病的患者患骨质疏松症的风险很高，因为他们有多种导致骨矿物质密度降低的风险因素。这些因素包括缺乏运动、日照减少、营养不良以及使用可能导致骨矿物质密度降低的药物或治疗方法，如抗癫痫药物、生酮饮食和糖皮质激素。在本文中，我们综述了神经系统疾病患儿骨健康改变的相关机制，以及癫痫、脑瘫和杜氏肌营养不良症患者在骨健康方面的管理。
