抗反刍动物IgM抗体导致假阳性的罗斯-瓦勒类风湿因子滴度。
False-positive Rose-Waaler rheumatoid factor titre given by anti-ruminant IgM antibody.
作者信息
Johnson P M, Reading C A, Holborow E J, Holdstock D J
出版信息
Vox Sang. 1976;31(6):451-5. doi: 10.1111/j.1423-0410.1976.tb04461.x.
Abstract
An antibody against ruminant (goat, sheep, bovine) IgM is described which also cross-reacts with rabbit IgM. The antibody was found in the serum of a patient with adult coeliac disease and a selective IgA deficiency. This patient gave a false high Rose-Waaler rheumatoid factor titre due to the presence of the serum antibody to rabbit IgM that was capable of agglutinating rabbit antibody-sensitised erythrocytes.
摘要
一种针对反刍动物（山羊、绵羊、牛）免疫球蛋白M（IgM）的抗体被报道，它也与兔IgM发生交叉反应。该抗体在一名患有成人乳糜泻和选择性IgA缺乏症的患者血清中被发现。由于血清中存在能凝集兔抗体致敏红细胞的抗兔IgM抗体，该患者的罗斯 - 瓦勒类风湿因子滴度出现假高值。
Zotero 插件