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弥漫性特发性骨肥厚的古流行病学研究

A paleoepidemiologic study of diffuse idiopathic skeletal hyperostosis.

作者信息

Vidal P

机构信息

Anthropology laboratory, Bordeaux university I, Talence, France.

出版信息

Joint Bone Spine. 2000;67(3):210-4.

PMID:10875320
Abstract

OBJECTIVE

To investigate the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in ancient populations.

MATERIAL AND METHODS

We studied 38 women and 61 men aged at least 30 years at death, whose remains were recovered from four cemeteries of the High Middle Ages (VIth to VIIIth century) located in Lorraine (eastern France). Criteria previously developed by Crubézy and Crubézy-Ibanez for paleopathological studies were used to determine whether the skeletal remains exhibited definite, possible, probable, or no DISH.

RESULTS

Definite DISH with flowing ossification along the thoracic spine and ossification of peripheral enthesopathies was seen in 2.8 to 3.7% of the subjects from two cemeteries and in none from the other two cemeteries. Identical figures were found for possible DISH. The prevalence and male predominance s (nine of 13 subjects in any DISH category were males) were similar to those reported in contemporary studies and in other paleopathological studies.

CONCLUSION

In the absence of clinical data on the metabolic status of the study subjects, our results suggest that DISH in our subjects was a marker for older age at death.

摘要

目的

调查古代人群中弥漫性特发性骨肥厚(DISH)的患病率。

材料与方法

我们研究了38名女性和61名男性,他们至少30岁死亡,遗骸从位于法国东部洛林地区的中世纪盛期(公元6至8世纪)的四座墓地中发掘出来。采用Crubézy和Crubézy - Ibanez先前为古病理学研究制定的标准,来确定骨骼遗骸是否表现出明确、可能、疑似或无DISH。

结果

在两座墓地中,2.8%至3.7%的受试者出现沿胸椎的连续性骨化和外周附着点病骨化的明确DISH,另外两座墓地中未发现。疑似DISH的比例相同。患病率及男性占比(任何DISH类别中的13名受试者中有9名男性)与当代研究及其他古病理学研究报告的结果相似。

结论

由于缺乏关于研究对象代谢状况的临床数据,我们的结果表明,研究对象中的DISH是死亡时年龄较大的一个标志。

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引用本文的文献

1
Selective mortality in middle-aged American women with Diffuse Idiopathic Skeletal Hyperostosis (DISH).中年美国女性弥漫特发性骨肥厚症(DISH)患者的选择性死亡率。
PLoS One. 2018 Aug 28;13(8):e0202283. doi: 10.1371/journal.pone.0202283. eCollection 2018.
2
Metabolic factors in diffuse idiopathic skeletal hyperostosis - a review of clinical data.弥漫性特发性骨肥厚的代谢因素——临床数据综述
Open Rheumatol J. 2014 Dec 19;8:116-28. doi: 10.2174/1874312901408010116. eCollection 2014.