John T J, Devarajan L V, Balasubramanyan A
Bull World Health Organ. 1976;54(1):115-7.
In an attempt to improve the serological response of infants in warm climates to oral poliovirus vaccine (OPV), the authors administered to 79 children between 6 and 41 weeks of age trivalent and monovalent OPV containing a virus dose 10 times as high as that found in the standard vaccine. The seroconversion rates following one dose of this trivalent OPV were 42% to type 1 poliovirus, 85% to type 2, and 31% to type 3. These rates are only slightly better than those previously reported after one dose of standard trivalent OPV and much lower than those achieved after 3 doses. The seroconversion rates following one dose of the monovalent OPV of enhanced potency were 89%, 93%, and 76%, respectively. These rates are comparable to those achieved after 5 doses of the standard trivalent OPV. Thus the refractoriness of host response was only partly overcome by enhancing the virus inoculum 10-fold.
为提高温暖气候地区婴儿对口服脊髓灰质炎疫苗（OPV）的血清学反应，作者对79名6至41周龄的儿童接种了三价和单价OPV，其病毒剂量比标准疫苗高10倍。接种一剂这种三价OPV后的血清转化率分别为：脊髓灰质炎1型病毒42%，2型病毒85%，3型病毒31%。这些比率仅略高于之前报道的接种一剂标准三价OPV后的比率，且远低于接种3剂后的比率。接种一剂效力增强的单价OPV后的血清转化率分别为89%、93%和76%。这些比率与接种5剂标准三价OPV后的比率相当。因此，将病毒接种量提高10倍仅部分克服了宿主反应的难治性。
