Hucklebridge F, Lambert S, Clow A, Warburton D M, Evans P D, Sherwood N
Psychophysiology and Stress Research Group, Department of Biomedical Sciences, University of Westminster, London, UK.
Biol Psychol. 2000 May;53(1):25-35. doi: 10.1016/s0301-0511(00)00040-5.
Secretory immunoglobulin A (sIgA) measured in saliva, an index of mucosal immunity, has repeatedly been shown to be sensitive to psychological variables. Chronic stress is downregulatory whereas an acute psychological challenge induces mobilisation. We examined whether an acute manipulation of mood to induce negative hedonic tone would be downregulatory, as in the chronic stress paradigm and further, whether induction of positive mood might have opposite effects. Two separate experiments were conducted. In the first, mood manipulation was by mental recall and in the second by music. For both sIgA concentration and sIgA secretion rate there was a significant elevation in response to the mood manipulation by recall regardless of hedonic tone. There was some evidence that for sIgA secretion rate the response was more pronounced for positive mood. Mood induction by music also resulted in significant elevations in sIgA concentration and secretion rate and responses were not distinguished by mood valence. None of the mood induction procedures was associated with changes in free cortisol. In these studies, we found no evidence that transient lowering of mood was downregulatory for salivary sIgA. The predominant finding was of sIgA mobilisation.
唾液中分泌型免疫球蛋白A（sIgA）是黏膜免疫的一个指标，研究反复表明其对心理变量敏感。慢性应激具有下调作用，而急性心理挑战则会促使其动员。我们研究了像慢性应激范式那样，急性情绪操纵以诱导负性享乐基调是否会产生下调作用，此外，诱导正性情绪是否可能产生相反的效果。我们进行了两个独立实验。第一个实验中，通过心理回忆来操纵情绪，第二个实验中则通过音乐来操纵情绪。无论享乐基调如何，对于sIgA浓度和sIgA分泌率而言，通过回忆进行情绪操纵均会使其显著升高。有证据表明，对于sIgA分泌率，正性情绪的反应更为明显。通过音乐诱导情绪也会导致sIgA浓度和分泌率显著升高，且反应不受情绪效价的区分。没有任何一种情绪诱导程序与游离皮质醇的变化相关。在这些研究中，我们没有发现证据表明情绪的短暂降低会对唾液sIgA产生下调作用。主要的发现是sIgA的动员。
