Stone A A, Cox D S, Valdimarsdottir H, Jandorf L, Neale J M
J Pers Soc Psychol. 1987 May;52(5):988-93. doi: 10.1037//0022-3514.52.5.988.
In this study, we examined the secretory immune system, the body's first line of defense against invading organisms, and its relation to daily fluctuations of mood. Specifically, secretory immunoglobulin A (sIgA) was studied. Unlike other psychoimmunity studies that examined all sIgA protein regardless of specificity to invading organisms, ours examined an antigen-specific sIgA response to the oral administration of a harmless protein (rabbit albumin) and monitored the antibody produced in response to the protein. Dental students recorded their daily mood thrice weekly for 8 1/3 weeks, and parotid saliva was obtained from subjects during these contacts. Using a within-subjects analyses strategy, we found that antibody response was lower on days with high negative mood relative to days with lower negative mood, and conversely, sIgA antibody response was higher on days with high positive mood relative to days with lower positive mood. Results from total sIgA protein were in the opposite direction, although not significantly so. These results extend our knowledge of immunological changes and mood, and they suggest that minor life events' role in health may be mediated by the secretory immune system.
在本研究中，我们检测了分泌免疫系统，这是人体抵御入侵生物体的第一道防线，以及它与日常情绪波动的关系。具体而言，我们研究了分泌型免疫球蛋白A（sIgA）。与其他心理免疫学研究不同，那些研究检测了所有sIgA蛋白，而不考虑其对入侵生物体的特异性，我们的研究检测了对口服无害蛋白（兔白蛋白）的抗原特异性sIgA反应，并监测了针对该蛋白产生的抗体。牙科学生在8又1/3周的时间里每周三次记录他们的日常情绪，并且在这些接触期间从受试者身上获取腮腺唾液。使用受试者内分析策略，我们发现与负面情绪较低的日子相比，在负面情绪较高的日子里抗体反应较低，相反，与正面情绪较低的日子相比，在正面情绪较高的日子里sIgA抗体反应较高。总sIgA蛋白的结果则相反，尽管差异不显著。这些结果扩展了我们对免疫变化和情绪的认识，并且表明生活中的小事件在健康方面的作用可能由分泌免疫系统介导。
