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极低热量饮食治疗2型糖尿病肥胖患者

[Very-low-calorie diet in treatment of morbidly obese patient with diabetes mellitus type 2].

作者信息

ten Hove W R, de Meijer P H, Meinders A E

机构信息

Leids Universitair Medisch Centrum, afd. Algemene Interne Geneeskunde, Leiden.

出版信息

Ned Tijdschr Geneeskd. 2000 Jun 3;144(23):1089-92.

Abstract

A 40-year-old woman with type 2 diabetes mellitus, hypertension, central obesity (body mass index: 40 kg/m2) and mixed hyperlipidaemia was treated with oral hypoglycaemic, antihypertensive and hypolipidaemic drugs as well as with intramuscular insulin. She kept gaining weight and developed hiatus hernia with regurgitation. Treatment was changed to a very low caloric diet during 9 months. She lost 18 kg of body weight and all drugs could be discontinued, as she became normoglycaemic, normotensive and normolipidaemic. Obesity is a risk factor for insulin resistance and type 2 diabetes mellitus. To reach euglycaemia in overweight type 2 diabetics is a difficult task. Oral hypoglycaemic agents and insulin are often used in combination with dietary intervention without adequate results. Losing body weight should be first-line treatment. However, compliance with weight-reducing methods is often low. The pathophysiologic importance of significant weight loss in the treatment of (morbid) obesity in type 2 diabetic patients is great.

摘要

一名40岁女性,患有2型糖尿病、高血压、中心性肥胖(体重指数:40kg/m²)和混合型高脂血症,接受口服降糖药、降压药、降脂药以及胰岛素注射治疗。她体重持续增加,并出现了伴有反流的食管裂孔疝。在9个月期间,治疗改为极低热量饮食。她体重减轻了18kg,由于血糖、血压和血脂恢复正常,所有药物均可停用。肥胖是胰岛素抵抗和2型糖尿病的危险因素。使超重的2型糖尿病患者达到血糖正常是一项艰巨的任务。口服降糖药和胰岛素常与饮食干预联合使用,但效果不佳。减轻体重应作为一线治疗方法。然而,减肥方法的依从性往往较低。显著减轻体重在2型糖尿病患者(病态)肥胖治疗中的病理生理重要性很大。

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