Okoronkwo M O
St. Michael's Hospital for Women, Umuahia, Nigeria.
West Afr J Med. 1999 Jan-Mar;18(1):52-4.
Objective of this study was to determine possible relationship between body weight and incidence of uterine leiomyomas (UL) among women in Umuahia, South Eastern Nigeria. The study involved one hundred and fifty-one UL patients whose body mass indices were compared with those of age-matched controls. Incidence of UL was found to be related to body weight of women aged 26-40 years. Body mass index (BMI) is weight in kg divided by square of height in metres. Mean BMIs +/- standard deviation (SD) of UL patients were found to be significantly higher than those of controls: (26.85 +/- 5.32 vs 21.63 +/- 7.76, P = 0.036) for women aged 26-30 years; (24.52 +/- 4.01 vs 22.75 +/- 4.03, P = 0.027) for women aged 31-35 years; (26.56 +/- 4.92 vs 23.10 +/- 4.38, P = 0.032) for women aged 36-40 years. However, there was no significant difference between mean BMI +/- SD of UL patients aged 21-25 years and their age-matched controls (21.15 +/- 2.70 vs 22.91 +/- 3.30, P = 0.068). The level of significance was selected as P < 0.05. This study has revealed association between overweight (BMI > 25) and incidence of UL among women in Umuahia, Nigeria. It has enabled us to understand more about pathogenesis of UL. Weight reduction, therefore, may reduce the incidence and improve ovarian function.
本研究的目的是确定尼日利亚东南部乌穆阿希亚女性的体重与子宫平滑肌瘤（UL）发病率之间的可能关系。该研究纳入了151例UL患者，并将其体重指数与年龄匹配的对照组进行比较。研究发现，UL的发病率与26至40岁女性的体重有关。体重指数（BMI）是指体重（千克）除以身高（米）的平方。研究发现，UL患者的平均BMI±标准差（SD）显著高于对照组：26至30岁女性为（26.85±5.32 vs 21.63±7.76，P = 0.036）；31至35岁女性为（24.52±4.01 vs 22.75±4.03，P = 0.027）；36至40岁女性为（26.56±4.92 vs 23.10±4.38，P = 0.032）。然而，21至25岁UL患者的平均BMI±SD与其年龄匹配的对照组之间无显著差异（21.15±2.70 vs 22.91±3.30，P = 0.068）。显著性水平设定为P < 0.05。本研究揭示了尼日利亚乌穆阿希亚女性超重（BMI>25）与UL发病率之间的关联。这使我们对UL的发病机制有了更多了解。因此，减轻体重可能会降低发病率并改善卵巢功能。
